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GYKI 52466 dihydrochloride
CAS No. 102771-26-6
GYKI 52466 dihydrochloride ( GYKI52466 dihydrochloride )
产品货号. M10135 CAS No. 102771-26-6
GYKI 52466 是一种选择性、非竞争性、口服活性 AMPA 受体 (AMPAR) 拮抗剂，针对 AMPA 诱导的反应，IC50 为 10-20 uM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7857 | 有现货 |
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| 50MG | ￥16038 | 有现货 |
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| 100MG | ￥20250 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GYKI 52466 dihydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GYKI 52466 是一种选择性、非竞争性、口服活性 AMPA 受体 (AMPAR) 拮抗剂，针对 AMPA 诱导的反应，IC50 为 10-20 uM。
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产品描述GYKI 52466 is a selective, non-competitive, orally active AMPA receptor (AMPAR) antagonist with IC50 of 10-20 uM against AMPA-induced responses; displays >20-fold selectivity over kainate and NMDA receptors; shows anticonvulsant and neuroprotective properties.Alzheimer Disease Discontinued.
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体外实验GYKI 52466 (0.3-100 μM) inhibits inward currents activated by AMPA and Kainate receptor in cultured rat hippocampal neurons.
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体内实验GYKI 52466 (intraperitoneal injection; 1.76-13.2 mg/kg; once) treatment provides potent anticonvulsant protection against sound-induced seizures in DBA/2 mice. Animal Model:Male and female DBA/2 mice tested for sound-induced seizure responses Dosage:1.76-13.2 mg/kg Administration:Intraperitoneal injection; 1.76-13.2 mg/kg; once Result:Observed Maximal anticonvulsant protection after the i.p. treatment (5-15 min ).
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同义词GYKI52466 dihydrochloride
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通路Membrane Transporter/Ion Channel
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靶点iGluR
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受体iGluR
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研究领域Neurological Disease
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适应症Alzheimer Disease
化学信息
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CAS Number102771-26-6
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分子量366.24
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分子式C17H15N3O2.2HCl
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纯度>98% (HPLC)
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溶解度——
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SMILESNC1=CC=C(C2=NN=C(C)CC3=CC4=C(OCO4)C=C32)C=C1
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化学全称4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)-benzenamine dihydrochloride
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Tarnawa I, et al. Eur J Pharmacol. 1989 Aug 22;167(2):193-9.
2. Ouardouz M, et al. Neurosci Lett. 1991 Apr 15;125(1):5-8.
3. Donevan SD, et al. Neuron. 1993 Jan;10(1):51-9.
产品手册
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